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There is 1 airport in Cayo Largo Del Sur. Cayo Largo Del Sur Airport (CYO) is Cayo Largo Del Sur’s primary airport with at least domestic flights and international flights departing from its runways every week. As of today, airlines operate out of Cayo Largo Del Sur Airport (CYO). Cayo Largo Del Sur Airport (CYO) is 0.8 miles from Cayo Largo Del Sur and offers nonstop flights to cities.