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There is 1 airport in Sao Tome Island. Sao Tome Island Airport (TMS) is Sao Tome Island’s primary airport with at least domestic flights and international flights departing from its runways every week. As of today, airlines operate out of Sao Tome Island Airport (TMS). Sao Tome Island Airport (TMS) is 3.1 miles from Sao Tome Island and offers nonstop flights to cities.